ea0035p676 | Growth hormone IGF axis basic | ECE2014
Dlesk Anton
, Kamensky Gabriel
, Lazurova Ivica
, Kuzma Martin
, Jackuliak Peter
, Payer Juraj
Background: GH plays an important role in maintaining physiological morphology and function of the left ventricle (LV). In GH deficient (GHD) patients a systolic and/or diastolic LV dysfunction has been documented. LV systolic dysfunction results from reduced LV mass (LVM), which subsequently leads to a decrease of the LV ejection fraction (EF). Results from clinical trials evaluating the effect of GH replacement therapy on the morphological and functional changes of the LV in...